DATA ANALYSIS – Decoding lifetime environmental exposures

Understanding our lifetime exposure to various chemicals through the exposome offers a more comprehensive approach to protecting public health, supported by the ATHLETE project’s  advanced data analysis toolbox.
This blogpost provides an overview of the Athlete toolbox and how exposome researchers can use it to analyse data.
The impact of our environment on health

People are exposed to more chemical pollutants than ever before, whether it’s through personal care items, packaging, or pesticides.

By studying our lifetime exposure to our environment, or the human exposome, we get a broader, more interconnected view of how our environment shapes our health. This holistic approach, which moves away from solely studying individual exposures, allows us to safeguard public health.

There is a pressing need for more advanced data analysis to navigate the intricacies of the exposome, making research findings more robust and replicable. ATHLETE’s toolbox equips researchers with advanced statistical analysis methodologies and tools, pre-empting the next generation of analytical challenges in exposome research.

Navigating the complexities of the exposome

By providing researchers with open access and cutting-edge methodologies, the ATHLETE toolbox empowers them to uncover novel insights into the intricate relationships between environmental exposures and human health. ATHLETE’s toolbox is made up of a set of resources that allow researchers to conduct in-depth analyses and derive meaningful insights from large-scale exposome datasets.

Tailored to the unique challenges of exposome research, the resources within the toolbox allow researchers to:

  • Track how the environment affects our health over time.
  • Study the cumulative impact of multiple exposures on health.
  • Explore the molecular mechanisms underlying environmental influences on health.
  • Make more reliable cause-effect inferences about exposome-health links.
  • Securely collaborate and share knowledge with the exposome research community.

Building on DataSHIELD technology, one tool allows researchers to analyse datasets from different places without sharing them. Researchers can, therefore, work on complex analyses together while keeping each dataset private and secure, allowing for better collaboration with large networks, such as the European Human Exposome Network (EHEN).

Toolbox spotlight

ExposomeShiny

ExposomeShiny is an intuitive data analysis platform that streamlines exposome analyses, concentrating them into a single, efficient, and easy-to-use analytic tool. Researchers can use the software to handle data tasks commonly performed in exposome research such as data cleaning, association analyses, and complex data visualizations, and explore their findings —all within a user-friendly interface.

The toolbox contains:

  • Reports and data analysis guidelines, which help researchers define the most suitable analysis strategies for each problem.
  • E-learning materials, including online tutorials and interactive videos, which make complex data analyses in advanced platforms, like R programming language, more accessible.
  • New or adapted methodologies to tackle unresolved challenges in exposome data analysis.
  • Software and front-end applications that gather proposed strategies and analytical workflows making them easier to implement.

© The Author(s) 2021. Published by Oxford University Press on behalf of the International Epidemiological Association.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

Futureproofing exposome research

By providing tools that make exposome research more accessible, the toolbox also ensures early adoption by non-specialist researchers who may lack expertise in advanced analytical platforms. This paves the way for its use outside the scientific community by regulators and policymakers, which could revolutionise preventative care, increasing lifespans across Europe.

ATHLETE’s toolbox serves as proof of concept for more advanced versions bringing together resources from across the international exposome research community. The European Human Exposome Network is taking a first step in that direction by gathering a wide variety of tools from the across nine European projects studying how the exposome affects our health.

By embracing advanced analytical techniques and anticipating future challenges, the European Human Exposome Network is pushing the boundaries of exposome research and paving the way for discoveries in environmental health science.

Key Information