EPHOR

Exposome project for health and occupational research

The EPHOR project will lay the groundwork for evidence-based and cost-effective prevention to improve health at work by developing a working-life exposome toolbox. The total burden of disease caused by occupational exposure is estimated at 5-7%, similar to the burden resulting from urban air pollution or obesity. Given the associated societal and economic pressure, a healthy work environment is an important goal for government and industry. Current risk reduction policies and strategies are informed by existing scientific evidence. However, this evidence is limited due to the challenges of studying the complex relationship between exposure at and outside of work, and health.

We define the working-life exposome as all occupational and related non-occupational exposures (e.g. lifestyle, behaviour) throughout the course of life. Taking a working-life exposome approach will mean a great step for occupational health science. It will help address the current limitations and challenges by providing better insights into the relationships between exposure at work and disease at different life stages.

EPHOR will develop methods and tools to characterise the working-life exposome. By applying these to both existing data and for collection of new data, we will enhance our knowledge of the working-life exposome. EPHOR’s tools, methods and knowledge will be made available in a toolbox to scientists, policy makers and occupational health practitioners.

PARTICIPANTS
  • Institute of Applied Scientific Research (TNO), Netherlands (Project Coordination)
  • Aarhus University, Denmark
  • Barcelona Institute for Global Health (ISGlobal), Spain
  • Catholic University of Leuven, Belgium
  • Cyprus University of Technology, Cyprus
  • National Institute of Health and Medical Research (INSERM), France
  • Finnish Institute of Occupational Health, Finland
  • Institute of Occupational Medicine, United Kingdom
  • Interaktiv GmbH, Germany
  • Karolinska Institute, Sweden
  • Lifeglimmer GMBH, Germany
  • National School of Public Health, Greece
  • Norwegian Institute of Occupational Health, Norway
  • Owlstone Medical Limited, United Kingdom
  • University of Bergen, Norway
  • University of Manchester, United Kingdom
  • Utrecht University, Netherlands
  • Vtec Engineering BV, Netherlands
Coordinator
Dr Anjoeka Pronk
Senior Scientist, Netherlands Organization for Applied Scientific Research (TNO), Utrecht, The Netherlands
Dr Rob Stierum
Senior Scientist, Netherlands Organization for Applied Scientific Research (TNO), Utrecht, The Netherlands
PROJECT MANAGER

Dr Astrid Kruizinga

astrid.kruizinga@tno.nl

Public deliverables
Title Ref Participant Format Due
Protocol for the collection, pre- processing and storage of biological samples D3.1 Report
Protocol for feasibility study D1.3 Report
Report on automated job coding D4.4 Report
Inventory of European cohorts with extensive information on occupational exposures D5.1
Protocol of study on working life exposome and respiratory health D6.1
Report on the external exposome protocol development for the case studies D1.4
Report on collection and defining JEMs D2.1
Report on tutorial for the application of a suite of ‘multiple exposure methods’ D4.1
Report on tutorial on the use of hierarchical models in working-life exposome research D4.3
Report on harmonizing existing JEMs D2.2
Report on protocol for including new data in EuroJEM D2.3
Report on development of new and more specific JEMs D2.4
Report on the establishment of the EPHOR mega cohort D5.2
Part 1: Web-based toolbox version 1.0 D9.1
Report on inventory of ETR models relevant for EPHOR D4.2
Report on dynamic coding for more meaningful categories for exposure assessment D4.5
Report on methods and results passive sampling method D1.2
Report describing the outcome of bioinformatics analysis on omics data (pathway and exposome stratification) D3.4
Report describing the biomonitoring, omics and bioassays methods on traditional biological matrices including quality control D3.2
Tools and guidance on exposome health impact assessment to feed into WP9 D8.3
Report on method development for processing of sensor data D1.5
Report on evaluation and transition into dynamic EuroJEM D2.5
Report on quantification of internal biological pathways in relation to external exposome D4.6
Protocol (including results of analyses) for future studies on respiratory health based on combining the EPHOR mega cohort approach with the detailed case study approach D5.5
Protocol (including results of analyses) for future studies on shift work based on combining the EPHOR mega cohort approach with the detailed case study approach D5.6
Protocol (including results of analyses) for future studies on respiratory health based on combining the EPHOR mega cohort approach with the detailed case study approach D6.4
Protocol for future studies on shift work based on combining the EPHOR mega cohort approach with the detailed case study approach including replica D7.4
Part 2: Web-based toolbox version 2.0 D9.2

January 28, 2020