Mapping exposure-induced immune effects: connecting the exposome and the immunome

The EXIMIOUS consortium—gathering experts in immunology, toxicology, clinical medicine, environmental hygiene, epidemiology, bioinformatics and sensor development—will bring about a new way of assessing the human exposome by linking innovative ways of characterizing and quantifying multiple and combined environmental exposures (exposomics) with high-dimensional immunophenotyping and profiling platforms to map early immune effects induced by these exposures (immunomics).

In several cohorts—covering the entire lifespan, including prenatal life—we will map exposome, immune system (immunome), and other omics and clinical and socio-economic data, using two main methodologies—one starting from the exposome, the other starting from health effects—that ‘meet in the middle’.

We will use novel bioinformatics tools, based on systems immunology and machine learning to integrate and analyse these datasets and to construct ‘immune fingerprints’ that reflect a person’s lifetime exposome and identify ‘immune fingerprints’ that are early signs of poor health and predictors of disease at an individual level.

Project flyer (click image to download)
Project videos

The EXIMIOUS project periodically organises topical symposia (webinars) related to environmental and occupational exposures and measurements, exposure and immunity, and gene-immune-environment interactions. Watch the latest one below

Key publications

Read the Eximious project profile paper published in Environmental Epidemiology.  A full list of scientific publications linked to the project is available here.

Public deliverables

For the full list of public deliverables, click here.

Prof Peter Hoet
Head, Unit of Environment and Health. KU Leuven, Belgium

Please use this contact form to get in touch with the project team.


Catholic University of Leuven, Belgium (Project Coordination)

Aarhus University, Denmark

Accelopment, Switzerland

Babraham Institute, United Kingdom

Belgian Center for Occupational Hygiene Belgium

Biogenity BioG, Denmark

Copenhagen Capital Region Denmark

IMEC, Belgium

Louvain Centre for Toxicology and Applied Pharmacology, Belgium

Norwegian Institute of Public Health, Norway

National Research Centre for the Working Environment, Denmark

Queen’s University Belfast, United Kingdom

University of Hasselt, Belgium

University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania

Vall D’Hebron Research Institute, Spain

January 28, 2020