The EXIMIOUS consortium—gathering experts in immunology, toxicology, clinical medicine, environmental hygiene, epidemiology, bioinformatics and sensor development—will bring about a new way of assessing the human exposome by linking innovative ways of characterizing and quantifying multiple and combined environmental exposures (exposomics) with high-dimensional immunophenotyping and profiling platforms to map early immune effects induced by these exposures (immunomics).
In several cohorts—covering the entire lifespan, including prenatal life—we will map exposome, immune system (immunome), and other omics and clinical and socio-economic data, using two main methodologies—one starting from the exposome, the other starting from health effects—that ‘meet in the middle’.
We will use novel bioinformatics tools, based on systems immunology and machine learning to integrate and analyse these datasets and to construct ‘immune fingerprints’ that reflect a person’s lifetime exposome and identify ‘immune fingerprints’ that are early signs of poor health and predictors of disease at an individual level.
The EXIMIOUS project periodically organises topical symposia (webinars) related to environmental and occupational exposures and measurements, exposure and immunity, and gene-immune-environment interactions. Watch the latest one below
For the full list of public deliverables, click here.
Catholic University of Leuven, Belgium (Project Coordination)
Aarhus University, Denmark
Babraham Institute, United Kingdom
Belgian Center for Occupational Hygiene Belgium
Biogenity BioG, Denmark
Copenhagen Capital Region Denmark
Louvain Centre for Toxicology and Applied Pharmacology, Belgium
Norwegian Institute of Public Health, Norway
National Research Centre for the Working Environment, Denmark
Queen’s University Belfast, United Kingdom
University of Hasselt, Belgium
University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania
Vall D’Hebron Research Institute, Spain